Acyclovir injection adverse reactions
The adverse reactions listed below have been observed in controlled and uncontrolled clinical trials in approximately 700 patients who received Acyclovir at ~ 5 mg/kg (250 mg/m2) three times daily, and approximately 300 patients who received ~ 10 mg/kg (500 mg/m2) three times daily.
The most frequent adverse reactions reported during administration of Acyclovir were inflammation or phlebitis at the injection site in approximately 9% of the patients, and transient elevations of serum creatinine or BUN in 5% to 10% (the higher incidence occurred usually following rapid [less than 10 minutes] intravenous infusion). Nausea and/or vomiting occurred in approximately 7% of the patients (the majority occurring in nonhospitalized patients who received 10 mg/kg). Itching, rash or hives occurred in approximately 2% of patients. Elevation of transaminases occurred in 1% to 2% of patients.
The following hematologic abnormalities occurred at a frequency of less than 1%: anemia, neutropenia, thrombocytopenia, thrombocytosis, leukocytosis, and neutrophilia. In addition, anorexia and hematuria were observed.
Observed During Clinical Practice
In addition to adverse events reported from clinical trials, the following events have been identified during post-approval use of Acyclovir for injection in clinical practice. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. These events have been chosen for inclusion due to either their seriousness, frequency of reporting, potential causal connection to acyclovir, or a combination of these factors.
General
Anaphylaxis, angioedema, fatigue, fever, headache, pain, peripheral edema.
Digestive
Abdominal pain, diarrhea, gastrointestinal distress, nausea.
Cardiovascular
Hypotension.
Hemic and Lymphatic
Disseminated intravascular coagulation, hemolysis, leukocyto-lastic vasculitis, leukopenia, lymphadenopathy.
Hepatobiliary Tract and Pancreas
Elevated liver function tests, hepatitis, hyperbilirubinemia, jaundice.
Musculoskeletal
Myalgia.
Nervous
Aggressive behavior, agitation, ataxia, coma, confusion, delirium, dizziness, dysarthria, encephalopathy, hallucinations, obtundation, paresthesia, psychosis, seizure, somnolence, tremor. These symptoms may be marked, particularly in older adults.
Skin
Alopecia, erythema multiforme, photosensitive rash, pruritus, rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria. Severe local inflammatory reactions including tissue necrosis, have occurred following infusion of Acyclovir into extravascular tissues.
Special Senses
Visual abnormalities
Urogenital
Renal failure, elevated blood urea nitrogen, elevated creatinine.
Click here to order Acyclovir, U.S. orders only
All other countries click here to buy Acyclovir
Related posts:
