Acyclovir injection description
Acyclovir is a synthetic nucleoside analog active against herpes viruses. Acyclovir for Injection USP is a sterile lyophilized powder for intravenous administration only. Each 500 mg vial contains 500 mg of Acyclovir and 49 mg of sodium, and each 1000 mg vial contains 1000 mg Acyclovir and 98 mg of sodium. Reconstitution of the 500 mg or 1000 mg vials with 10 mL or 20 mL, respectively, of Sterile Water for Injection, results in a solution containing 50 mg/mL of acyclovir. The pH of the reconstituted solution is approximately 11. Further dilution in any appropriate intravenous solution must be performed before infusion.
Acyclovir sodium is a white, crystalline powder with a molecular weight of 247.19, and a maximum solubility in water at 25°C exceeds 100 mg/mL. Each 500 mg or 1000 mg vial of Acyclovir for injection USP when reconstituted with 10 mL or 20 mL, respectively, sterile diluent yields 50 mg/mL Acyclovir (pH approximately 11). At physiologic pH, Acyclovir exists as the un-ionized form with a molecular weight of 225.21 and a maximum solubility in water at 37°C of 2.5 mg/mL. The pka’s of Acyclovir are 2.27 and 9.25.
The chemical name of Acyclovir sodium is 9-[(2-Hydroxyethoxy)methyl]guanine sodium salt.
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