Amoxicillin dosage and administration
Acute Uncomplicated Gonorrhea
Adults
PO 3 g as a single dose.
Prepubertal Children (2 yr of age and older)
PO Amoxicillin 50 mg/kg combined with probenecid 25 mg/kg as a single dose.
Ear, Nose, Throat, Skin and Skin Structure, GU Tract Infections
Adults and Children Weighing at least 40 kg Mild to moderate infections
PO 500 mg every 12 h or 250 mg every 8 h.
Severe infections
PO 875 mg every 12 h or 500 mg every 8 h.
Children (older than 3 mo of age and weighing less than 40 kg) Mild to moderate infections
PO 25 mg/kg/day in divided doses every 12 h or 20 mg/kg/day in divided doses every 8 h.
Severe infections
PO 45 mg/kg/day in divided doses every 12 h or 40 mg/kg/day in divided doses every 8 h.
H. Pylori Eradication
Adults Triple Therapy
PO Amoxicillin 1 g, clarithromycin 500 mg, and lansoprazole 30 mg all given twice daily (every 12 h) for 14 days.
Dual therapy
PO Amoxicillin 1 g and lansoprazole 30 mg each given 3 times daily (every 12 h) for 14 days.
Impaired Renal Function
Adults
PO Glomerular filtration rate (GFR) of 10 to 30 mL/min: Administer 500 or 250 mg every 12 h, depending on the severity of the infection.
GFR less than 10 mL/min
Administer 500 or 250 mg every 24 h, depending on the severity of the infection.
Hemodialysis patients
Administer 500 or 250 mg every 24 h, depending on the severity of the infection, plus an additional dose during and at the end of dialysis.
ER tablet
Not recommended in patients with CrCl less than 30 mL/min.
Lower Respiratory Tract Infections
Adults and Children Weighing at least 40 kg
PO 875 mg every 12 h or 500 mg every 8 h.
Children (older than 3 mo of age and weighing less than 40 kg)
PO 45 mg/kg/day in divided doses every 12 h or 40 mg/kg/day in divided doses every 8 h.
Tonsillitis, Pharyngitis
Adults and Children 12 yr and older
PO ER tablet: 775 mg once daily, within 1 h of finishing a meal, for 10 days.
General Advice
* In neonates and infants 12 wk of age and younger, the recommended maximum dosage is 30 mg/kg/day divided every 12 h.
* After reconstitution, the required amount of suspension should be placed directly on the child’s tongue for swallowing. Alternatively, add required amount of suspension to formula, milk, fruit juice, water, ginger ale, or cold drink.
* Except for gonorrhea, treatment should be continued for a minimum of 48 to 72 h after the patient becomes asymptomatic or evidence of bacterial eradication has been obtained.
* At least 10 days of treatment for any infection caused by S. pyogenes is recommended to prevent acute rheumatic fever.
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