Amoxicillin drug interactions
Chloramphenicol, macrolide antibiotics (eg, erythromycin), sulfonamides
May impair bactericidal effects of amoxicillin.
Contraceptives, oral
May reduce efficacy of oral contraceptives.
Methotrexate
Methotrexate plasma levels may be elevated, increasing the risk of toxicity.
Probenecid
Renal tubular secretion of amoxicillin may be reduced, resulting in increased and prolonged amoxicillin blood levels.
Tetracyclines
May impair bactericidal effects of amoxicillin.
Laboratory Test Interactions
May cause false-positive urine glucose test results with Benedict solution, Fehling solution, or Clinitest tablets (enzyme-based tests [eg, Clinistix , Tes-Tape ] are recommended); false-positive direct Coombs test result in certain patient groups; false-positive protein reactions with sulfosalicylic acid and boiling test, acetic acid test, biuret reaction and nitric acid test (bromphenol blue test, Multistix , is recommended).
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