Amoxicillin Pharmacokinetics
Amoxicillin Absorption
Rapidly absorbed. T max is 1 to 2 h; C max is 3.5 mcg/mL (250 mg dose), 5 mcg/mL (500 mg dose), and approximately 13.8 mcg/mL (875 mg dose).
Extended-release
C max is 6.6 mcg/mL; T max is 3.1 h.
Amoxicillin Distribution
Diffuses into most body tissues and fluids; penetration in CNS is poor unless meninges are inflamed. Approximately 20% protein bound.
Amoxicillin Elimination
Half-life is 61.3 min; approximately 60% excreted in the urine within 6 to 8 h as unchanged drug.
Categories: Amoxicillin
