Some medical conditions may interact with Aciphex . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
* if you are pregnant, planning to become pregnant, or are breast-feeding
* if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
* if you have allergies to medicines, foods, or other substances
* if you have liver problems or stomach or bowel cancer
Some MEDICINES MAY INTERACT with Aciphex . Tell your health care provider if you are taking any other medicines, especially any of the following:
* Clarithromycin or voriconazole because they may increase the risk of Aciphex ’s side effects
* Anticoagulants (eg, warfarin), cyclosporine, or digoxin because the risk of their side effects may be increased by Aciphex
* Azole antifungals (eg, ketoconazole), HIV protease inhibitors (eg, atazanavir), or iron because their effectiveness may be decreased by Aciphex
This may not be a complete list of all interactions that may occur. Ask your health care provider if Aciphex may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
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* you are allergic to any ingredient in Aciphex or to similar medicines (eg, omeprazole)
* you are taking an HIV protease inhibitor (eg, atazanavir)
Contact your doctor or health care provider right away if any of these apply to you.
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Treating heartburn or irritation of the esophagus caused by gastroesophageal reflux disease (GERD). It may be used for short-term treatment of ulcers of the small intestine. It may be used with certain antibiotics to treat ulcers of the small intestine and to help prevent them from coming back. It may be used to treat conditions that cause your body to make too much stomach acid (eg, Zollinger-Ellison syndrome). It may also be used for other conditions as determined by your doctor.
Aciphex is a proton pump inhibitor. It works by decreasing the amount of acid produced in the stomach.
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Rabeprazole is available with a prescription under the brand name Aciphex. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medicine, especially if it is new to you.
* Aciphex 20 mg – light yellow, enteric-coated tablets


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The following drugs can interact with Aciphex. Tell your doctor if you are using any of these:
* atazanavir (Reyataz);
* a blood thinner such as warfarin (Coumadin);
* clopidogrel (Plavix);
* digoxin (digitalis, Lanoxin);
* ketoconazole (Nizoral); or
* cyclosporine (Gengraf, Sandimmune, Neoral).
This list is not complete and there may be other drugs that can interact with Aciphex. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.
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Get emergency medical help if you have any of these signs of an allergic reaction to Aciphex: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Less serious Aciphex side effects may include:
* headache;
* upset stomach or diarrhea;
* insomnia or nervousness; or
* a rash or itching.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Follow your doctor’s instructions about any restrictions on food, beverages, or activity while you are using Aciphex.
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Seek emergency medical attention if you think you have used too much of this medicine.
Symptoms of an overdose are not known.
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Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.
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Take Aciphex exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
Aciphex is usually given for 4 to 8 weeks only. Your doctor may recommend a second course of treatment if you need additional healing time.
When treating H. pylori infection, Aciphex may be needed for only 7 days. Follow your doctor’s instructions.
Take this medicine with a full glass (8 ounces) of water.
Aciphex may be taken with or without food.
Do not crush, break, or chew a Aciphex tablet. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or crushing the pill would cause too much of the drug to be released at one time. Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before your treatment is completed. Store Aciphex at room temperature away from moisture and heat.
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