Prescription drugs info

* Instruct patient to take colchicine regularly to prevent acute attacks.
* Instruct patient not to exceed 8 mg in course of therapy for acute attack. To minimize cumulative toxicity, patient should wait 3 days before starting second course.
* Advise patient with gout to drink at least 2,000 mL of fluid daily, unless contraindicated.
* Reinforce health care provider’s instructions about weight loss, diet, and alcohol intake.
* Advise patient to have extra supply of drug on hand in case health care provider gives instructions to increase dosage.
* Instruct patient to stop taking drug if nausea, vomiting, diarrhea, or abdominal pain occurs, especially if patient has history of spastic colon or ulcers.

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Nausea, severe abdominal pain, vomiting, diarrhea, shock, ST segment elevation, paralysis, respiratory failure, liver damage, renal failure, leukopenia, thrombocytopenia, coagulopathy, alopecia, stomatitis.

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Monitor

Colchicine Blood counts precautions
Check blood counts periodically in patients undergoing long-term therapy.

Colchicine Toxicity signs precautions
Assess for signs of toxicity (eg, abdominal pain, alopecia, nausea, vomiting, diarrhea, myopathy, peripheral neuritis). Notify health care provider immediately if these signs occur.

Colchicine Uric acid/Creatinine precautions
Monitor serum uric acid and creatinine throughout therapy.

Colchicine Pregnancy precautions
Category C (oral).

Colchicine Children precautions
Safety and efficacy not established.

Colchicine Elderly precautions
Administer with great caution to elderly and debilitated patients.

Colchicine Hepatic Function precautions
Increased colchicine toxicity may occur.

Colchicine GI reactions precautions
Drug may cause nausea, vomiting, diarrhea, and abdominal pain that may aggravate pre-existing peptic ulcer or spastic colon. Discontinue drug if these symptoms appear.

Colchicine Myopathy and neuropathy precautions
Myoneuropathy may occur and cause weakness in patients with impaired kidney function; serum creatine kinase may be elevated. Usually resolves in 3 to 4 wk after drug withdrawal.

Colchicine Vitamin B 12 malabsorption precautions
Colchicine induces reversible malabsorption of vitamin B 12 with long-term use.

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Colchicine dermatologic adverse reactions
Dermatoses; purpura; alopecia.

Colchicine GI adverse reactions
Nausea; vomiting; diarrhea; abdominal pain.

Colchicine Hematologic adverse reactions
Bone marrow depression with aplastic anemia; agranulocytosis, leukopenia or thrombocytopenia (long-term therapy).

Colchicine Hepatic adverse reactions
Elevated alkaline phosphatase and AST.

Colchicine Miscellaneous adverse reactions
Reversible azoospermia; myopathy; peripheral neuritis.

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Acute Gouty Arthritis Colchicine Adults dosage
Initial dose (give at first sign of attack) PO 1.2 mg; then 0.6 every h or 1.2 mg every 2 h until pain is relieved or diarrhea ensues. Total dose is usually 4 to 8 mg. Wait 3 days before initiating a second course of therapy.

Prophylaxis Colchicine Adults dosage
PO 0.6 mg/day for 3 to 4 days/wk if fewer than 1 attack/yr; if more than 1 attack/yr, 0.6 mg/day. Severe cases may require 1.2 to 1.8 mg/day.

Surgical Patients Colchicine Adults dosage
PO 0.6 mg 3 times daily for 3 days before and 3 days after surgery.

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Serious GI, renal, hepatic, or cardiac disorders; blood dyscrasias.

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Treatment and relief of pain in attacks of acute gouty arthritis; regular prophylaxis between attacks and is often effective in aborting an attack when taken at the first sign of articular discomfort.

Colchicine Unlabeled Uses
Familial Mediterranean fever; hepatic cirrhosis; primary biliary cirrhosis; treatment of Behcet disease; scleroderma; Sweet syndrome.

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Colchicine Absorption
Rapidly absorbed. T max is 0.5 to 2 h.

Colchicine Distribution
Large amounts present in bile and intestinal secretions. High concentrations also found in kidney, liver, and spleen. About 50% protein bound. Vd is 1 to 3 L/kg.

Colchicine Metabolism
Undergoes enterohepatic recirculation. Deacetylated primarily by the liver.

Colchicine Elimination
Plasma t ½ to 10 to 60 min. Excreted via biliary and renal routes; 10% to 20% excreted unchanged in urine.

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Inhibits inflammation and reduces pain and swelling associated with gouty arthritis.

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* If you have any questions about Colchicine , please talk with your doctor, pharmacist, or other health care provider.
* Colchicine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
* If your symptoms do not improve or if they become worse, check with your doctor.

This information is summary only. It does not contain all information about Colchicine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

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