Colchicine Usual Adult Dose for Acute Gout:
Oral:
Initial: Gout Flare: 1.2 mg orally at the first sign of the flare followed by 0.6 mg one hour later.
Maximum: Gout Flare: 1.8 mg orally over a one hour period
Co-administration with strong CYP3A4 inhibitors:
0.6 mg orally followed by 0.3 mg one hour later. Dose to be repeated no earlier than 3 days.
Co-administration with moderate CYP3A4 inhibitors:
1.2 mg orally for one dose only. Dose to be repeated no earlier than 3 days.
Co-administration with P-glycoprotein inhibitors:
0.6 mg orally for one dose only. Dose to be repeated no earlier than 3 days.
Colchicine Usual Adult Dose for Familial Mediterranean Fever:
1.2 mg to 2.4 mg orally daily, administered in 1 or 2 divided doses
The dose should be increased as needed to control disease and as tolerated in increments of 0.3 mg/day to a maximum recommended daily dose. If intolerable side effects develop, the dose should be decreased in increments of 0.3 mg/day.
Co-administration with strong CYP3A4 inhibitors: 0.6 mg orally daily, may be given as 0.3 mg twice a day.
Co-administration with moderate CYP3A4 inhibitors: 1.2 mg orally daily, may be given as 0.6 mg twice a day.
Co-administration with P-glycoprotein inhibitors: 0.6 mg orally daily, may be given as 0.3 mg twice a day.
Colchicine Usual Adult Dose for Gout — Prophylaxis:
(Unlabeled use):
Oral:
0.5 to 0.6 mg orally once a day for 3 to 4 days a week (less than 1 attack/year).
0.5 to 0.6 mg orally once a day (greater than 1 attack/year).
Severe cases may require 1 to 1.8 mg/day.
Colchicine Usual Adult Dose for Biliary Cirrhosis:
(Unlabeled use):
0.6 mg orally twice a day.
Colchicine Usual Adult Dose for Sarcoidosis:
(Unlabeled use):
0.6 mg orally twice a day.
Colchicine Usual Adult Dose for Pseudogout — Prophylaxis:
(Unlabeled use):
0.6 mg orally twice a day.
Colchicine Usual Adult Dose for Fibromatosis:
(Unlabeled use):
Initial: 0.6 to 1.2 mg orally once a day each day for the first 1 to 2 weeks.
Maintenance: 0.6 to 1.2 mg orally once a day 1 to 2 times per week is often used to prevent recurrence of fibromatosis.
Colchicine Usual Adult Dose for Aphthous Stomatitis — Recurrent:
(Unlabeled use):
0.5 to 0.6 mg orally daily. The dose may be titrated upward while the patient is observed for signs of toxicity.
Colchicine Usual Adult Dose for Behcet’s Disease:
(Unlabeled use):
0.5 to 1.5 mg orally once a day.
Study (n=116)
Dosage adjusted to body weight:
less than 50 Kg: 1 mg daily
50 to 59 Kg: 1 mg and 1.5 mg on alternate days
60 to 75 Kg: 1.5 mg daily
76 to 84 Kg: 1.5 and 2 mg on alternate days
greater than or equal to 85 Kg: 2 mg daily
Colchicine Usual Adult Dose for Constipation — Chronic:
(Unlabeled use):
Study (n=16)
0.6 mg orally three times daily for 4 weeks
Colchicine Usual Adult Dose for Sweet’s Syndrome:
(Unlabeled use):
0.6 mg orally twice daily.
Colchicine Usual Pediatric Dose for Familial Mediterranean Fever:
Oral:
4 to 6 years: 0.3 to 1.8 mg daily, administered in 1 or 2 divided doses.
6 to 12 years: 0.9 to 1.8 mg daily, administered in 1 or 2 divided doses.
Over 12 years: 1.2 to 2.4 mg daily, administered in 1 or 2 divided doses.
The dose should be increased as needed to control disease and as tolerated in increments of 0.3 mg/day to a maximum recommended daily dose. If intolerable side effects develop, the dose should be decreased in increments of 0.3 mg/day.
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