Celexa breastfeeding warnings
Celexa is excreted in human milk. Side effects have been reported in two nursing infants. The manufacturer recommends that a decision should be made to discontinue nursing or discontinue the drug taking into account the importance of the drug to the mother.
One study has reported that the relative dose to a suckling infant is similar to that reported for fluoxetine, and higher than that reported for fluvoxamine, paroxetine, or sertraline. Two cases have been reported of infants experiencing excessive somnolence, decreased feeding, and weight loss in relation to breast-feeding from a mother receiving Celexa. Milk/serum concentration ratios based on single pairs of samples from the two patients ranged from 1.16 to 1.88. Based on this, the absolute dose a suckling infant may ingest would be in the range of 4.3 to 17.6 micrograms/kg. The relative dose would be 0.7% to 5.9% of the weight- adjusted maternal dose. In one case the infant was reported to have recovered completely once the infant’s mother discontinued the Celexa. According to another case report, the relative infant Celexa dose from breast milk is approximately 9% of the weight- adjusted maternal dose. A study of seven women taking Celexa and their infants has reported that the plasma concentrations of Celexa and demethylCelexa in the infants were very low or absent and there were no adverse effects.
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