Celexa nervous system side effects
Nearly all selective serotonin reuptake inhibitors, mixed serotonin/norepinephrine reuptake inhibitors, and tricyclic antidepressants cause sleep abnormalities to some extent. These antidepressants have marked dose-dependent effects on rapid eye movement (REM) sleep, causing reductions in the overall amount of REM sleep over the night and delays the first entry into REM sleep (increased REM sleep onset latency (ROL)), both in healthy subjects and depressed patients. The antidepressants that increase serotonin function appear to have the greatest effect on REM sleep. The reduction in REM sleep is greatest early in treatment, but gradually returns towards baseline during long-term therapy; however, ROL remains long. Following discontinuation of therapy the amount of REM sleep tends to rebound. Some of these drugs (i.e., bupropion, mirtazapine, nefazodone, trazodone, trimipramine) appear to have a modest or minimal effect on REM sleep.
Nervous system side effects including headache (26%), dry mouth (20%), increased sweating (11%), tremor (8%), dizziness (2%), and sleep abnormalities have been reported. Paresthesia, and migraine have been reported frequently. Hyperkinesia, vertigo, hypertonia, extrapyramidal disorder, leg cramps, involuntary muscle contractions, hypokinesia, neuralgia, dystonia, abnormal gait, hypesthesia and ataxia have been reported infrequently. Neuroleptic malignant syndrome, serotonin syndrome, abnormal coordination, hyperesthesia, ptosis, stupor, and choreoathetosis have rarely been reported. Akathisia, dyskinesia, and grand mal convulsions have been reported to be temporally associated with Celexa treatment.
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